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Severe combined immunodeficiency (SCID) is a genetic disease that can lead to severe deterioration of the immune system. Among the key genes related to SCID, RAG1 and IL2RG play a crucial role. IL2RG ...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibodies and involvement of multiple systems. The occurrence of SLE is due to the body's loss of tolerance t...
中南大学湘雅三医院的曹科团队在Oncogene上发表了题为 “CD8+ T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer” 的研究论文。
肉芽肿是免疫细胞在各种器官形成的肿块。大多数肉芽肿看起来没有结构，但它们与淋巴器官有一些相似之处。为了更好地理解肉芽肿的形成，本文对结节病患者的肉芽肿进行了原位单细胞精准定量和空间转录多组学分析，并用...
非小细胞肺癌是肺癌中最常见的病理类型，大多数患者在确诊时已属晚期。对于驱动基因突变阴性的患者而言，目前的治疗仍以化疗为主，总体预后较差，改善治疗现状、获得长期生存是晚期患者最迫切的需求。随着肿瘤免疫治...
肿瘤相关巨噬细胞（Tumor-associated macrophages, TAMs）是浸润在肿瘤组织中的巨噬细胞，是肿瘤微环境中最多的免疫细胞，主要被认为具有促肿瘤作用。目前，靶向缺失TAMs已被用于肿瘤免疫治疗领域。同时，TAMs的表型...
